Endocrine Abstracts

Introduction: Insulin resistance (IR) and visceral obesity, elements of metabolic syndrome (MS), contribute to hyperandogenaemia and may lead to hirsutism and other signs of hyperandrogenism. Little is known about the influence of metformin therapy (MET) on hormonal profile in women with MS and IR without menstrual irregularity.Aim: To asses the influence of MET on sex steroids concentrations in young women with MS.Methods: The stu...

Introduction: The incidence of the thyroid carcinoma (TC) is relatively low, although its increase has been observed in the last 20 years.Aim: A comparative clinical and epidemiological analysis of two cohorts of patients surgically treated for the thyroid diseases in the Endocrine Surgery Department in Cracow during two five-year periods: 1982–1986 and 2000–2005.Material and methods: Two subsets of patients, who underwen...

Measuring of goiter by ultrasonography is one of the generally accepted methods for iodine nutrition assessment. Discordance between previously used and lately proposed thyroid volume (TV) reference values (TVRV) is the subject of discussion and makes it difficult to properly interpret the effects of iodine prophylaxis.Aim: To establish TVRV for Polish schoolchildren population.Material and methods: 2903 schoolchildren aged 6–...

Introduction: In acromegalic patients the incidence of benign and malignant neoplasms, appears to be higher than that in the standard population. Our aim was to evaluate the incidence of tumours in acromegalic patients treated at our Department.Materials and methods: Over the years 1983–2008, 101 acromegalic patients (mean age 51.8±15.4 years), were diagnosed and treated in our Department. Pituitary macroadenoma and microadenoma were stated in ...

Introduction: Multiple endocrine neoplasia (MEN) is a rare disease. Apart from the well recognised MEN2 syndrome the MEN1 is less common diagnosed. The MEN1 gene is localised on the 11q13 chromosome and encodes menin. There is no simple definition of MEN1 syndrome because of heterogenous combination over 20 different endocrine and non-endocrine tumours. According to the Gubbio consensus, MEN1 is diagnosed by the occurrence of two of the three main MEN1-related endocrine tumour...

Introduction: Metformin (MET) is mainly used in diabetes mellitus type 2 (DM2) therapy. Little is known about its effects in patients with metabolic syndrome (MS) and insulin resistance (IR) without DM2.Aim: To asses the influence of MET on carbohydrate metabolism in young prediabetic women with MS.Materials and methods: The study population: 30 women with MS aged 25–45 years before (M1) and after (M2) ME...

Introduction: Metabolic syndrome (MS) is connected to atherogenic dyslipidemia. Data concerning influence of metformin (MET) therapy on lipid profile in nondiabetic women with MS remains unclear.Aim: To asses the influence of MET on selected lipid, apolipoproteins AI, B concentrations and atherogenic indexes values in young women with MS.Materials and methods: The study population: 30 women with MS aged 25–45 years before (M<s...

Introduction: Radioiodine treatment of hyperthyroidism of ophthalmopathy (GO) patients may cause or aggravate GO (in some 15%). We evaluated the activity and severity of ophthalmopathy in patients who acquired GO following radioiodine therapy.Materials and methods: Over the years 2003–2005, 1500 hyperthyroid patients were treated with radioiodine at our Clinic. Of these, 50.9% suffered from Graves’ disease. Following their radioiodine treatment...

Adrenocortical carcinoma (ACC) is a rare neoplasm with poor prognosis. Patients present signs of hormone excess: virilisation, Cushing’s syndrome or only enlarged abdominal mass. Incidentally ACC can be also detected in the ultrasonography. Some of ‘non-hypersecretory’ ACCs can produce non-bioactive hormones steroid precursors or not very big amount of them and sometimes patients present subclinical Cushing’s symptoms. Surgery and adjuvant radiotherapy and ...

Pituitary abscess is a very rare entity, only 200 cases (mostly the complication of the pituitary surgery) has been described so far.We want to present the case of pituitary abscess arising from Rathke’s cyst.Case report: Seventy-years-old female treated due to clinical depression, was admitted to the Endocrinology Department because of profound hyponatremia (serum Natrium 119 mmol/l). She was diagnosed with plurihormonal ante...